Lipid Mediators and Human Leukemic Blasts

Lipid Mediators and Human Leukemic Blasts

Some of the most potent inflammatory mediators share a lipid origin. They regulate a wide spectrum of cellular processes including cell proliferation and apoptosis. However, the precise roles and ways (if any) in which these compounds impact the growth and apoptosis of leukemic blasts remain incompletely resolved. In spite of this, significant advances have been recently made. Here we briefly r...

Human Vγ9Vδ2 T cells specifically recognize and kill acute myeloid leukemic blasts.

Vγ9Vδ2 T cells are attractive candidates for antileukemic activity. The analysis of Vγ9Vδ2 T cells in newly diagnosed acute myeloid leukemia (AML) patients revealed that their absolute cell numbers were normal in the blood as well as in the bone marrow but showed a striking imbalance in the differentiation subsets, with preponderance of the effector memory population. This unusual phenotype was...

Lipid mediators in allergy: Link between human and animal models.

Leukemic Blasts From Patients With Acute Myeloid Leukemias

A CUTE LEUKEMIAS are regarded as disorders characterized by a diffenentiative block of the hemopoietic precursors, which results in an unnegulated accumulation of immature blood cells.”2 Several in vitro experiments have shown that this block can be overcome by a wide variety ofchemical compounds;”3 based on these reports, new strategies of treatment have been proposed for leukemia therapy. Suc...

in vitro evaluation of cytarabin induced apoptosis in leukemic blasts

apoptosis, or active cell death, is a specific mode of cell death, which is characterized by morphological changes such as chromatin condensation, fragmentation of the nucleus, cytoplasmic retraction and appearance of apoptotic bodies' containing apparently intact organelles. apoptosis occurs in physiological conditions as a regulatory mechanism of tissue growth, where cell proliferation is bal...